What is the main question the study attempts to answer?
The authors of this preprint set out to investigate the structure-function relationship of the huntingtin (HTT) protein, in its apo form, as it undergoes polyglutamine expansion, a mutation which results in Huntington’s disease. This builds upon previous work by these researchers (Vijayvargia et al 2016 eLIFE ) which investigates polyglutamine tract-dependent modulation of HTT structure and function.