Introduction:
Bullous pemphigoid is one of the most common blistering dermatosis which is characterized by autoantibodies against hemidesmosomal proteins mucosa including the oral cavity, nose, eyes and genital area in addition to skin (1). Hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized by persistent hypereosinophilia leading to possible organ damage with cutaneous manifestations or systematic ones (2). Several cases of BP with coexisting HES have been reported in the literature. Peripheral eosinophilia which are reported in both BP and HES are not only important in indicating the severity of both diseases, but also play a role as a pathogenic factor in these diseases (3). We describe a female patient who was initially diagnosed with bullous pemphigoid. Later because of the unresponsiveness for usual treatment to BP and because of persistent eosinophilia, the diagnosis of idiopathic hypereosinophilic syndrome associated with BP was made.