Introduction:
Bullous pemphigoid is one of the most common blistering dermatosis which
is characterized by autoantibodies against hemidesmosomal proteins
mucosa including the oral cavity, nose, eyes and genital area in
addition to skin (1). Hypereosinophilic syndrome (HES) is a
myeloproliferative disorder characterized by persistent
hypereosinophilia leading to possible organ damage with cutaneous
manifestations or systematic ones (2). Several cases of BP with
coexisting HES have been reported in the literature. Peripheral
eosinophilia which are reported in both BP and HES are not only
important in indicating the severity of both diseases, but also play a
role as a pathogenic factor in these diseases (3). We describe a female
patient who was initially diagnosed with bullous pemphigoid. Later
because of the unresponsiveness for usual treatment to BP and because of
persistent eosinophilia, the diagnosis of idiopathic hypereosinophilic
syndrome associated with BP was made.