3.8 The network of differently expressed lncRNA-gene coexpression in ERAD
In the brain and nerve ganglion, the collaboration between the differentially expressed (DE-) lncRNAs and the differentially expressed (DE-) mRNAs showed 5,086 pairs with co-expression which were composed of 26 DE-lncRNAs and 1,328 DE-mRNAs. In these DE-lncRNAs and DE-mRNAs, significantly correlated lncRNA-mRNA couplings were obtained from 19 DE-lncRNAs and 6 DE-mRNAs in ERDA, based on a Pearson correlation coefficient with |R| > 0.95 and P-value < 0.05, and PDIs.2 (degree=17) indicating the highest degrees (Figure 11A). The 6 DE-mRNAs showed a similar model of expression in the brain (Figure 11B) and ganglion (Figure 11C). The lncRNA-mRNA coupling suggested that the regulation of PDIs.2 by multiple lncRNAs was likely to occur in the nervous system. The mRNAs in the co-expression network enriched in ERDA may play a critical role in the growth of male M. rosenbergii which is worth further study.